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Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes

Hjort, Rebecka (author)
Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden
Ahlqvist, Emma (author)
Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden
Andersson, Tomas (author)
Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden; Reg Stockholm, Ctr Occupat & Environm Med, SE-11365 Stockholm, Sweden
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Alfredsson, Lars (author)
Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden; Reg Stockholm, Ctr Occupat & Environm Med, SE-11365 Stockholm, Sweden
Carlsson, Per-Ola (author)
Uppsala universitet,Uppsala University,Transplantation och regenerativ medicin
Grill, Valdemar (author)
Norwegian University of Science and Technology,Norwegian Univ Sci & Technol, NTNU, Dept Clin & Mol Med, NO-7491 Trondheim, Norway
Groop, Leif (author)
Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden; Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland
Martinell, Mats, 1971- (author)
Uppsala universitet,Uppsala University,Allmänmedicin och preventivmedicin
Sørgjerd, Elin Pettersen (author)
St. Olav’s University Hospital,Norwegian University of Science and Technology,Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, HUNT Res Ctr, NO-7491 Trondheim, Norway; Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olays Hosp, NO-7006 Trondheim, Norway
Tuomi, Tiinamaija (author)
Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),Helsinki University Central Hospital,University of Helsinki,Lund Univ, Clin Res Ctr, Dept Clin Sci Malmö, SE-20502 Malmö, Sweden; Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland; Univ Helsinki, Helsinki Univ Hosp, Abdominal Ctr, Res Program Diabet & Obes,Div Endocrinol, FI-00250 Helsinki, Finland; Folkhälsan Res Ctr, FI-00250 Helsinki, Finland
Åsvold, Bjørn Olav (author)
St. Olav’s University Hospital,Norwegian University of Science and Technology,Norwegian Univ Sci & Technol, NTNU, Dept Publ Hlth & Nursing, HUNT Res Ctr, NO-7491 Trondheim, Norway; Trondheim Reg & Univ Hosp, Dept Endocrinol, St Olays Hosp, NO-7006 Trondheim, Norway; Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, NTNU, KG Jebsen Ctr Genet Epidemiol, NO-7491 Trondheim, Norway
Carlsson, Sofia (author)
Karolinska Institutet,Karolinska Institute,Karolinska Inst, Inst Environm Med, Nobels Väg 13, SE-17177 Stockholm, Sweden
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 (creator_code:org_t)
2020-08-24
2020
English 12 s.
In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 105:11
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. METHODS: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (≥ 30 minutes of moderate activity 3 times/week) self-reported leisure time PA, compared to sedentariness. RESULTS: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. MAIN CONCLUSIONS: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

gene-environment interaction
LADA
latent autoimmune diabetes in adults
physical activity
population-based
type 2 diabetes
ANDIS
diabetes
physical activity

Publication and Content Type

art (subject category)
ref (subject category)

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